Ontology highlight
ABSTRACT:
SUBMITTER: Srivastava AK
PROVIDER: S-EPMC6777340 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Srivastava Amit K AK Banerjee Ananya A Cui Tiantian T Han Chunhua C Cai Shurui S Liu Lu L Wu Dayong D Cui Ri R Li Zaibo Z Zhang Xiaoli X Xie Guozhen G Selvendiran Karuppaiyah K Patnaik Srinivas S Karpf Adam R AR Liu Jinsong J Cohn David E DE Wang Qi-En QE
Cancer research 20190320 9
Cancer stem cells (CSC) play a central role in cancer metastasis and development of drug resistance. miRNA are important in regulating CSC properties and are considered potential therapeutic targets. Here we report that miR-328-3p (miR-328) is significantly upregulated in ovarian CSC. High expression of miR-328 maintained CSC properties by directly targeting DNA damage binding protein 2, which has been shown previously to inhibit ovarian CSC. Reduced activity of ERK signaling in ovarian CSC, mai ...[more]