Ontology highlight
ABSTRACT:
SUBMITTER: Nozaki S
PROVIDER: S-EPMC6777367 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nozaki Shohei S Castro Araya Roiner Francisco RF Katoh Yohei Y Nakayama Kazuhisa K
Biology open 20190917 9
The intraflagellar transport (IFT) machinery, which includes the IFT-A and IFT-B complexes, mediates bidirectional trafficking of ciliary proteins. In addition to these complexes, the BBSome, which is composed of eight subunits that are encoded by the causative genes of Bardet-Biedl syndrome (BBS), has been proposed to connect the IFT machinery to ciliary membrane proteins, such as G protein-coupled receptors, to mediate their export from cilia. However, little is known about the connection betw ...[more]