Ontology highlight
ABSTRACT:
SUBMITTER: Zhong Y
PROVIDER: S-EPMC6778111 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhong Yifei Y Lee Kyung K Deng Yueyi Y Ma Yueming Y Chen Yiping Y Li Xueling X Wei Chengguo C Yang Shumin S Wang Tianming T Wong Nicholas J NJ Muwonge Alecia N AN Azeloglu Evren U EU Zhang Weijia W Das Bhaskar B He John Cijiang JC Liu Ruijie R
Nature communications 20191004 1
Arctigenin (ATG) is a major component of Fructus Arctii, a traditional herbal remedy that reduced proteinuria in diabetic patients. However, whether ATG specifically provides renoprotection in DKD is not known. Here we report that ATG administration is sufficient to attenuate proteinuria and podocyte injury in mouse models of diabetes. Transcriptomic analysis of diabetic mouse glomeruli showed that cell adhesion and inflammation are two key pathways affected by ATG treatment, and mass spectromet ...[more]