Ontology highlight
ABSTRACT:
SUBMITTER: Lipper CH
PROVIDER: S-EPMC6778226 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Lipper Colin H CH Stofleth Jason T JT Bai Fang F Sohn Yang-Sung YS Roy Susmita S Mittler Ron R Nechushtai Rachel R Onuchic José N JN Jennings Patricia A PA
Proceedings of the National Academy of Sciences of the United States of America 20190916 40
MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human maladies including diabetes, cancer, neurodegeneration, and Parkinson's diseases. In healthy cells, mitoNEET receives its clusters from the mitochondrion and transfers them to acceptor proteins in a process that could be altered by drugs or during illness. Here, we report that mitoNEET regulates the outer-mitochondria ...[more]