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Inflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia.


ABSTRACT: OBJECTIVES:To investigate changes in inflammatory biomarkers during induction therapy for older adults with acute myeloid leukemia (AML) and their associations with geriatric assessment (GA) measures and outcomes. METHODS:This was a single institution ancillary study to a prospective observational study (N?=?20 consecutive adults aged ?60 with newly diagnosed AML who received induction chemotherapy). Biomarkers (Interleukin-6 [IL-6], IL-6 soluble receptor [IL-6 sR], tumor necrosis factor alpha [TNF?], TNF? soluble receptor 1 [TNF? sR1], interleukin-3 [IL-3], C-reactive protein [CRP]) were collected at start of induction, weekly for three weeks, and post-induction and were compared over time using paired t-tests. GA was administered at baseline and post-induction, and correlated with biomarker levels using Spearman correlations. Survival was estimated using Kaplan-Meier and compared by categorized biomarker level using Wilcoxon tests. RESULTS:Biomarker levels were stable during induction, except for CRP and IL-6 sR. Declines in objectively measured physical function [Short Physical Performance Battery (SPPB); r?=?0.71, p?

SUBMITTER: Loh KP 

PROVIDER: S-EPMC6778500 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Inflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia.

Loh Kah Poh KP   Tooze Janet A JA   Nicklas Barbara J BJ   Kritchevsky Stephen B SB   Williamson Jeff D JD   Ellis Leslie R LR   Powell Bayard L BL   Pardee Timothy S TS   Goyal Neha G NG   Klepin Heidi D HD  

Journal of geriatric oncology 20190405 3


<h4>Objectives</h4>To investigate changes in inflammatory biomarkers during induction therapy for older adults with acute myeloid leukemia (AML) and their associations with geriatric assessment (GA) measures and outcomes.<h4>Methods</h4>This was a single institution ancillary study to a prospective observational study (N = 20 consecutive adults aged ≥60 with newly diagnosed AML who received induction chemotherapy). Biomarkers (Interleukin-6 [IL-6], IL-6 soluble receptor [IL-6 sR], tumor necrosis  ...[more]

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