Ontology highlight
ABSTRACT:
SUBMITTER: Akahoshi Y
PROVIDER: S-EPMC6778639 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Akahoshi Yu Y Nishiwaki Satoshi S Mizuta Shuichi S Ohashi Kazuteru K Uchida Naoyuki N Tanaka Masatsugu M Fukuda Takahiro T Ozawa Yukiyasu Y Takahashi Satoshi S Onizuka Makoto M Shiratori Souichi S Nakamae Hirohisa H Kanda Yoshinobu Y Ichinohe Tatsuo T Atsuta Yoshiko Y Kako Shinichi S
Cancer science 20190829 10
Tyrosine kinase inhibitor (TKI) administration after allogeneic hematopoietic stem cell transplantation (HSCT) may carry a survival benefit in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Therefore, we investigated whether TKI prophylaxis for negative-minimal residual disease (MRD) after HSCT would improve patient outcomes in this nationwide retrospective cohort study. We included patients with Ph+ ALL who underwent their first allogeneic HSCT between 2001 and 2016, r ...[more]