Ontology highlight
ABSTRACT:
SUBMITTER: Zhi L
PROVIDER: S-EPMC6778692 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhi Lianteng L Qin Qi Q Muqeem Tanziyah T Seifert Erin L EL Liu Wencheng W Zheng Sushuang S Li Chenjian C Zhang Hui H
Neurobiology of aging 20181102
Mutations and deletions in PTEN-induced kinase 1 (PINK1) cause autosomal recessive Parkinson's disease (PD), the second most common neurodegenerative disorder. PINK1 is a nuclear-genome encoded Ser/Thr kinase in mitochondria. PINK1 deletion was reported to affect dopamine (DA) levels in the striatum and mitochondrial functions but with conflicting results. The role of PINK1 in mitochondrial function and in PD pathogenesis remains to be elucidated thoroughly. In this study, we measured DA release ...[more]