Ontology highlight
ABSTRACT:
SUBMITTER: Koruza K
PROVIDER: S-EPMC6778848 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Koruza K K Lafumat B B Nyblom M M Mahon B P BP Knecht W W McKenna R R Fisher S Z SZ
Acta crystallographica. Section D, Structural biology 20190822 Pt 10
Human carbonic anhydrase IX (CA IX) expression is upregulated in hypoxic solid tumours, promoting cell survival and metastasis. This observation has made CA IX a target for the development of CA isoform-selective inhibitors. To enable structural studies of CA IX-inhibitor complexes using X-ray and neutron crystallography, a CA IX surface variant (CA IX<sub>SV</sub>; the catalytic domain with six surface amino-acid substitutions) has been developed that can be routinely crystallized. Here, the pr ...[more]