Ontology highlight
ABSTRACT:
SUBMITTER: Schaenzer AJ
PROVIDER: S-EPMC6779124 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
ACS infectious diseases 20180815 10
As antibiotic resistance rises, there is a need for strategies such as antibiotic adjuvants to conserve already-established antibiotics. A family of bacterial kinases known as the penicillin-binding-protein and serine/threonine kinase-associated (PASTA) kinases has attracted attention as targets for antibiotic adjuvants for β-lactams. Here, we report that the pyrazolopyridazine GW779439X sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to various β-lactams through inhibition of the ...[more]