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Synthesis of a C1-C23 fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.

ABSTRACT: A convergent synthesis of a C1-C23 fragment of the archazolids has been completed based on a high yielding Stille coupling to costruct the substituted Z,Z,E-conjugated triene. After removal of the protecting groups, the resulting tetrol exhibited evidence for inhibition of the vacuolar-type ATPase (V-ATPase) but not cyclooxygenase (COX) inhibitory activity.

SUBMITTER: O'Neil GW

PROVIDER: S-EPMC6779165 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Synthesis of a C1-C23 fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.

O'Neil Gregory W GW Craig Alexander M AM Williams John R JR Young Jeffrey C JC Spiegel P Clint PC

Synlett : accounts and rapid communications in synthetic organic chemistry 20170208 9

A convergent synthesis of a C1-C23 fragment of the archazolids has been completed based on a high yielding Stille coupling to costruct the substituted Z,Z,E-conjugated triene. After removal of the protecting groups, the resulting tetrol exhibited evidence for inhibition of the vacuolar-type ATPase (V-ATPase) but not cyclooxygenase (COX) inhibitory activity. ...[more]

PMID: 31592212

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