Ontology highlight
ABSTRACT:
SUBMITTER: Kaiko GE
PROVIDER: S-EPMC6779314 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Kaiko Gerard E GE Chen Feidi F Lai Chin-Wen CW Chiang I-Ling IL Perrigoue Jacqueline J Stojmirović Aleksandar A Li Katherine K Muegge Brian D BD Jain Umang U VanDussen Kelli L KL Goggins Bridie J BJ Keely Simon S Weaver Jessica J Foster Paul S PS Lawrence Daniel A DA Liu Ta-Chiang TC Stappenbeck Thaddeus S TS
Science translational medicine 20190301 482
There is a major unmet clinical need to identify pathways in inflammatory bowel disease (IBD) to classify patient disease activity, stratify patients that will benefit from targeted therapies such as anti-tumor necrosis factor (TNF), and identify new therapeutic targets. In this study, we conducted global transcriptome analysis to identify IBD-related pathways using colon biopsies, which highlighted the coagulation gene pathway as one of the most enriched gene sets in patients with IBD. Using th ...[more]