Ontology highlight
ABSTRACT:
SUBMITTER: Perera KD
PROVIDER: S-EPMC6779346 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Perera Krishani Dinali KD Rathnayake Athri D AD Liu Hongwei H Pedersen Niels C NC Groutas William C WC Chang Kyeong-Ok KO Kim Yunjeong Y
Veterinary microbiology 20190823
Feline infectious peritonitis (FIP) is a highly fatal disease caused by a virulent feline coronavirus in domestic and wild cats. We have previously reported the synthesis of potent coronavirus 3C-like protease (3CLpro) inhibitors and the efficacy of a protease inhibitor, GC376, in client-owned cats with FIP. In this study, we studied the effect of the amino acid changes in 3CLpro of feline coronavirus from a feline patient who received antiviral treatment for prolonged duration. We generated rec ...[more]