Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC6779383 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Wu Yi Y Wang Yingzheng Y Liu Qiang Q Zhu Lihua Julie LJ Gao Hui H Cui Maosheng M Liu Jinghao J Zhao Pengju P Liu Jianfeng J Chen Lei L Wang Jinyong J Zeng Wenxian W Woodruff Teresa K TK Zeng Shenming S
RNA biology 20190715 10
Mammalian fertility is reduced during heat exposure in the summer, but is regained as temperatures decrease in the autumn again. However, the mechanism underlying the phenomenon remains unknown. We investigated heat stress tolerance of germ cells and their surrounding somatic cells, and discovered that microRNA ssc-ca-1 was upregulated after heat stress in cultured porcine granulosa cells (GCs), but not in serum-starved GCs. Ssc-ca-1 inhibited heat shock protein 70 (Hsp70) expression through its ...[more]