Ontology highlight
ABSTRACT:
SUBMITTER: Duchemin AL
PROVIDER: S-EPMC6779468 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
eLife 20190916
Mechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development in vivo. Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, albeit active in diffe ...[more]