Ontology highlight
ABSTRACT:
SUBMITTER: Demeyer A
PROVIDER: S-EPMC6779721 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Demeyer Annelies A Van Nuffel Elien E Baudelet Griet G Driege Yasmine Y Kreike Marja M Muyllaert David D Staal Jens J Beyaert Rudi R
Frontiers in immunology 20191001
MALT1 plays an important role in innate and adaptive immune signaling by acting as a scaffold protein that mediates NF-κB signaling. In addition, MALT1 is a cysteine protease that further fine tunes proinflammatory signaling by cleaving specific substrates. Deregulated MALT1 activity has been associated with immunodeficiency, autoimmunity, and cancer in mice and humans. Genetically engineered mice expressing catalytically inactive MALT1, still exerting its scaffold function, were previously show ...[more]