Ontology highlight
ABSTRACT:
SUBMITTER: Ashrafian F
PROVIDER: S-EPMC6779730 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ashrafian Fatemeh F Shahriary Arefeh A Behrouzi Ava A Moradi Hamid Reza HR Keshavarz Azizi Raftar Shahrbanoo S Lari Arezou A Hadifar Shima S Yaghoubfar Rezvan R Ahmadi Badi Sara S Khatami Shohre S Vaziri Farzam F Siadat Seyed Davar SD
Frontiers in microbiology 20191001
Recent evidence suggests that probiotics can restore the mucosal barrier integrity, ameliorate inflammation, and promote homeostasis required for metabolism in obesity by affecting the gut microbiota composition. In this study, we investigated the effect of <i>Akkermansia muciniphila</i> and its extracellular vesicles (EVs) on obesity-related genes in microarray datasets and evaluated the cell line and C57BL/6 mice by conducting RT-PCR and ELISA assays. <i>A. muciniphila</i>-derived EVs caused a ...[more]