Ontology highlight
ABSTRACT:
SUBMITTER: Rudolph J
PROVIDER: S-EPMC6779796 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in immunology 20191001
The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, proliferation and integrin activation is well-accepted. We previously demonstrated that conventional ADAP knockout mice show a significantly attenuated course of experimental autoimmune encephalomyelitis (EAE). To dissect the impact of different ADAP expres ...[more]