Unknown

Dataset Information

0

Two New Cytotoxic Compounds from a Deep-Sea Penicillum citreonigrum XT20-134.

ABSTRACT: Penicillum citreonigrum XT20-134 (MCCC 3A00956) is a fungus with cytotoxic activity, derived from deep-sea sediment. Five new compounds, adeninylpyrenocine (1), 2-hydroxyl-3-pyrenocine-thio propanoic acid (2), ozazino-cyclo-(2,3-dihydroxyl-trp-tyr) (3), 5,5-dichloro-1-(3,5-dimethoxyphenyl)-1,4-dihydroxypentan-2-one (4), and 2,3,4-trihydroxybutyl cinnamate (5), together with 19 known compounds (6-24), were isolated from an ethyl acetate (EtOAc) extract of its fermentation. The structures of the new compounds were comprehensively characterized by high-resolution electrospray ionization-mass spectrometry (HR-ESI-MS), 1D and 2D nuclear magnetic resonance (NMR). All isolates were evaluated for their cytotoxic activities. The heteroatom-containing new compounds 2 and 4 showed potent cytotoxicity to the human hepatoma tumor cell Bel7402 with IC50 values of 7.63 ± 1.46, 13.14 ± 1.41 ?M and the human fibrosarcoma tumor cell HT1080 with IC50 values of 10.22 ± 1.32, 16.53 ± 1.67 ?M, respectively.

SUBMITTER: Tang XX 

PROVIDER: S-EPMC6780507 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Two New Cytotoxic Compounds from a Deep-Sea <i>Penicillum citreonigrum</i> XT20-134.

Tang Xi-Xiang XX   Liu Shun-Zhi SZ   Yan Xia X   Tang Bo-Wen BW   Fang Mei-Juan MJ   Wang Xiu-Min XM   Wu Zhen Z   Qiu Ying-Kun YK  

Marine drugs 20190829 9

<i>Penicillum citreonigrum</i> XT20-134 (MCCC 3A00956) is a fungus with cytotoxic activity, derived from deep-sea sediment. Five new compounds, adeninylpyrenocine (<b>1</b>), 2-hydroxyl-3-pyrenocine-thio propanoic acid (<b>2</b>), ozazino-<i>cyclo</i>-(2,3-dihydroxyl-trp-tyr) (<b>3</b>), 5,5-dichloro-1-(3,5-dimethoxyphenyl)-1,4-dihydroxypentan-2-one (<b>4</b>), and 2,3,4-trihydroxybutyl cinnamate (<b>5</b>), together with 19 known compounds (<b>6</b>-<b>24</b>), were isolated from an ethyl aceta  ...[more]

Similar Datasets

Unknown Deep-Sea Anemones Are Prospective Source of New Antimicrobial and Cytotoxic Compounds.
| S-EPMC8704684 | biostudies-literature
Unknown Two new cytotoxic indole alkaloids from a deep-sea sediment derived metagenomic clone.
| S-EPMC4012447 | biostudies-literature
Unknown Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum.
| S-EPMC4878012 | biostudies-literature
Unknown Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea.
| S-EPMC8151441 | biostudies-literature
Unknown Cytotoxic and antimicrobial activities of two new sesquiterpenoids from red sea brittle star Ophiocoma dentata.
| S-EPMC9114132 | biostudies-literature
Unknown A new cytotoxic sesquiterpene quinone produced by Penicillium sp. F00120 isolated from a deep sea sediment sample.
| S-EPMC3280531 | biostudies-literature
Unknown Tetroazolemycins A and B, two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012.
| S-EPMC3707159 | biostudies-other
Unknown Cytotoxic polyketides from the deep-sea-derived fungus Engyodontium album DFFSCS021.
| S-EPMC4278208 | biostudies-literature
Unknown Cytotoxic Polyketides from a Deep-Sea Sediment Derived Fungus Diaporthe phaseolorum FS431.
| S-EPMC6749523 | biostudies-literature
Unknown Cytotoxic Polyketides Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum MCCC 3A00292.
| S-EPMC6950755 | biostudies-literature