Dataset Information

Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea.

ABSTRACT: Three new lavandulylated flavonoids, (2S,2''S)-6-lavandulyl-7,4'-dimethoxy-5,2'-dihydroxylflavanone (1), (2S,2''S)-6-lavandulyl-5,7,2',4'-tetrahydroxylflavanone (2), and (2''S)-5'-lavandulyl-2'-methoxy-2,4,4',6'-tetrahydroxylchalcone (3), along with seven known compounds 4-10 were isolated from culture broth of Streptomyces sp. G248. Their structures were established by spectroscopic data analysis, including 1D and 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configurations of 1-3 were resolved by comparison of their experimental and calculated electronic circular dichroism spectra. Compounds 1-3 exhibited remarkable antimicrobial activity. Whereas, two known compounds 4 and 5 exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv with minimum inhibitory concentration (MIC) values of 6.0 µg/mL and 11.1 µg/mL, respectively.

SUBMITTER: Cao DD

PROVIDER: S-EPMC6780759 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea.

Cao Duc Danh DD Trinh Thi Thanh Van TTV Mai Huong Doan Thi HDT Vu Van Nam VN Le Hong Minh HM Thi Quyen Vu QV Nguyen Mai Anh MA Duong Thu Trang TT Tran Dang Thach DT Chau Van Minh VM Ma Rui R Shetye Gauri G Cho Sanghyun S Murphy Brian T BT Pham Van Cuong VC

Marine drugs 20190910 9

Three new lavandulylated flavonoids, (2S,2''S)-6-lavandulyl-7,4'-dimethoxy-5,2'-dihydroxylflavanone (1), (2S,2''S)-6-lavandulyl-5,7,2',4'-tetrahydroxylflavanone (2), and (2''S)-5'-lavandulyl-2'-methoxy-2,4,4',6'-tetrahydroxylchalcone (3), along with seven known compounds 4-10 were isolated from culture broth of Streptomyces sp. G248. Their structures were established by spectroscopic data analysis, including 1D a ...[more]

PMID: 31510079

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Dataset Information

Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea.

Publications

Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived <i>Streptomyces</i> sp. G248 in East Vietnam Sea.

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