Ontology highlight
ABSTRACT:
SUBMITTER: Zhu W
PROVIDER: S-EPMC6781011 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhu Wenhan W Miyata Naoteru N Winter Maria G MG Arenales Alexandre A Hughes Elizabeth R ER Spiga Luisella L Kim Jiwoong J Sifuentes-Dominguez Luis L Starokadomskyy Petro P Gopal Purva P Byndloss Mariana X MX Santos Renato L RL Burstein Ezra E Winter Sebastian E SE
The Journal of experimental medicine 20190729 10
Chronic inflammation and gut microbiota dysbiosis, in particular the bloom of genotoxin-producing <i>E. coli</i> strains, are risk factors for the development of colorectal cancer. Here, we sought to determine whether precision editing of gut microbiota metabolism and composition could decrease the risk for tumor development in mouse models of colitis-associated colorectal cancer (CAC). Expansion of experimentally introduced <i>E. coli</i> strains in the azoxymethane/dextran sulfate sodium colit ...[more]