Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura K
PROVIDER: S-EPMC6781430 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nakamura Kuniyuki K Ikeuchi Tomoko T Nara Kazuki K Rhodes Craig S CS Zhang Peipei P Chiba Yuta Y Kazuno Saiko S Miura Yoshiki Y Ago Tetsuro T Arikawa-Hirasawa Eri E Mukouyama Yoh-Suke YS Yamada Yoshihiko Y
The Journal of cell biology 20190920 10
Ischemic stroke causes blood-brain barrier (BBB) breakdown due to significant damage to the integrity of BBB components. Recent studies have highlighted the importance of pericytes in the repair process of BBB functions triggered by PDGFRβ up-regulation. Here, we show that perlecan, a major heparan sulfate proteoglycan of basement membranes, aids in BBB maintenance and repair through pericyte interactions. Using a transient middle cerebral artery occlusion model, we found larger infarct volumes ...[more]