Upregulation of SPDEF is associated with poor prognosis in prostate cancer.
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ABSTRACT:
SUBMITTER: Meiners J
PROVIDER: S-EPMC6781494 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Upregulation of SPDEF is associated with poor prognosis in prostate cancer.
Meiners Jan J Schulz Katharina K Möller Katharina K Höflmayer Doris D Burdelski Christoph C Hube-Magg Claudia C Simon Ronald R Göbel Cosima C Hinsch Andrea A Reiswich Viktor V Weidemann Sören S Izbicki Jacob R JR Sauter Guido G Jacobsen Frank F Möller-Koop Christina C Mandelkow Tim T Blessin Niclas C NC Lutz Florian F Viehweger Florian F Lennartz Maximillian M Fraune Christoph C Heinzer Hans H Minner Sarah S Bonk Sarah S Huland Hartwig H Graefen Markus M Schlomm Thorsten T Büscheck Franziska F
Oncology letters 20190919 5
SAM pointed domain-containing Ets transcription factor (SPDEF), a member of the ETS transcription factor family, has been associated with prostate cancer development; however, its role in tumour development and progression is controversial. In the present study, SPDEF expression was analysed on a tissue microarray with >12,000 prostate cancer samples. SPDEF expression levels were higher in most prostate cancer samples than in normal prostate epithelium, suggesting SPDEF was upregulated in cancer ...[more]
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