Ontology highlight
ABSTRACT:
SUBMITTER: Lee SG
PROVIDER: S-EPMC6781499 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lee Seul Gee SG Lee Jaeok J Kim Kyung Min KM Lee Kee-In KI Bae Yun Soo YS Lee Hwa Jeong HJ
Pharmaceutics 20190917 9
In a previous study, the specific NOX1/2/4 inhibitor Ewha-18278 was confirmed as a possible treatment for osteoporosis both in vitro and in vivo. Here, we investigated the pharmacokinetics (PK) of the compound by intravenous (IV) and oral administrations to rats. Dimethyl sulfoxide (DMSO)-based and diazepam injection-based formulations were used to dissolve the compound. In the latter formulation applicable to humans, the changes in PK parameters were monitored at two different concentrations (1 ...[more]