Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh AK
PROVIDER: S-EPMC6781882 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Asian journal of organic chemistry 20180608 8
We have developed a conceptually new generation of non-peptidic HIV-1 protease inhibitors incorporating novel structural templates inspired by nature. This has resulted in protease inhibitors with exceptional potency and excellent pharmacological and drug-resistance profiles. The design of a stereochemically defined <i>bis</i>-tetrahydrofuran (<i>bis</i>-THF) scaffold followed by modifications to promote hydrogen bonding interactions with the backbone atoms of HIV-1 protease led to darunavir, th ...[more]