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TIP-B1 promotes kidney clear cell carcinoma growth and metastasis via EGFR/AKT signaling.


ABSTRACT: Kidney clear cell carcinoma (KIRC) is the most prevalent kidney malignancy. Accumulating evidence shows that high expression of TIP-B1 correlates with development of tumor progression. However, the detailed functions of TIP-B1 in the KIRC remain to be further elucidated. Here, we firstly found TIP-B1 expression was significantly increased in KIRC compared with adjacent normal tissues. What's more, higher expression of TIP-B1 were correlated with aggressive clinico-pathological characteristics. In vitro assay found TIP-B1 knockdown dramatically inhibited KIRC cells proliferation, migration and invasion. In vivo assay found down regulated TIP-B1 could suppress tumor growth and metastasis. Mechanism analysis indicated that TIP-B1 could bind EGFR and suppress EGFR degradation, then promoted EGF-induced AKT signaling. Together, TIP-B1 could be applied as an independent risk factor to predict KIRC progression and metastasis. Targeting TIP-B1 might be a new potential therapeutic strategy for KIRC treatment.

SUBMITTER: Yin L 

PROVIDER: S-EPMC6782011 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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TIP-B1 promotes kidney clear cell carcinoma growth and metastasis via EGFR/AKT signaling.

Yin Lei L   Gao Shenglin S   Shi Heng H   Wang Keyi K   Yang Huan H   Peng Bo B  

Aging 20190927 18


Kidney clear cell carcinoma (KIRC) is the most prevalent kidney malignancy. Accumulating evidence shows that high expression of TIP-B1 correlates with development of tumor progression. However, the detailed functions of TIP-B1 in the KIRC remain to be further elucidated. Here, we firstly found TIP-B1 expression was significantly increased in KIRC compared with adjacent normal tissues. What's more, higher expression of TIP-B1 were correlated with aggressive clinico-pathological characteristics. I  ...[more]

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