Ontology highlight
ABSTRACT:
SUBMITTER: Bamber BA
PROVIDER: S-EPMC6782323 | biostudies-literature | 1999 Jul
REPOSITORIES: biostudies-literature
Bamber B A BA Beg A A AA Twyman R E RE Jorgensen E M EM
The Journal of neuroscience : the official journal of the Society for Neuroscience 19990701 13
Ionotropic GABA receptors generally require the products of three subunit genes. By contrast, the GABA receptor needed for locomotion in Caenorhabditis elegans requires only the unc-49 gene. We cloned unc-49 and demonstrated that it possesses an unusual overlapping gene structure. unc-49 contains a single copy of a GABA receptor N terminus, followed by three tandem copies of a GABA receptor C terminus. Using a single promoter, unc-49 generates three distinct GABAA receptor-like subunits by splic ...[more]