Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells.
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ABSTRACT:
SUBMITTER: Aranda-Abreu GE
PROVIDER: S-EPMC6782881 | biostudies-literature | 1999 Aug
REPOSITORIES: biostudies-literature
Publications
Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells.
Aranda-Abreu G E GE Behar L L Chung S S Furneaux H H Ginzburg I I
The Journal of neuroscience : the official journal of the Society for Neuroscience 19990801 16
The embryonic lethal abnormal vision (ELAV)-like proteins are mRNA-binding proteins that regulate mRNA stability. The neuronal members of this family are required for neuronal differentiation. We identified the binding region of purified HuD protein to a target neuronal mRNA encoding for the tau microtubule-associated protein and demonstrated an in vivo interaction between the ELAV-like protein and its target tau mRNA. We show that treatment of neuronal cells with antisense oligodeoxynucleotides ...[more]
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