Clinicopathological and prognostic value of preoperative plasma fibrinogen in gastric cancer patients: A meta-analysis.

ABSTRACT: BACKGROUND:Increasing evidence has revealed that plasma fibrinogen may serve as a prognostic indicator in multiple malignancies. However, there have been some conflicting findings on the prognostic value of plasma fibrinogen in gastric cancer (GC). We conducted a meta-analysis to explore the correlation between plasma fibrinogen and clinic outcome in GC. METHODS:A comprehensive literature search was conducted using the Embase, the Web of Science, the Cochrane library, and PubMed databases. Combined hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were used to investigate the impact of elevated plasma fibrinogen on the prognosis and clinicopathological features of patients with GC. RESULTS:A total of 11 studies involving 8315 patients were selected for this meta-analysis. The pooled results suggested that elevated plasma fibrinogen in GC patients was related to worse overall survival (OS) (HR?=?1.57, 95% CI: 1.36-1.81, P?

SUBMITTER: Cheng F 

PROVIDER: S-EPMC6783169 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature