Ontology highlight
ABSTRACT:
SUBMITTER: Ferro LS
PROVIDER: S-EPMC6783262 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Ferro Luke S LS Can Sinan S Turner Meghan A MA ElShenawy Mohamed M MM Yildiz Ahmet A
eLife 20190909
Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm. Here, we tested the ability of single and multiple motors to bypass synthetic obstacles on MTs in vitro. Contrary to previous reports, we found that single mammalian dynein is highly capable of bypassing obstacles. Single human kinesin-1 motors fail to avoid obstacles, consistent with ...[more]