Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen MQ
PROVIDER: S-EPMC6783272 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
eLife 20191008
In mice, spared nerve injury replicates symptoms of human neuropathic pain and induces upregulation of many genes in somatosensory neurons. Here we used single cell transcriptomics to probe the effects of partial infraorbital transection of the trigeminal nerve at the cellular level. Uninjured neurons were unaffected by transection of major nerve branches, segregating into many different classes. In marked contrast, axotomy rapidly transformed damaged neurons into just two new and closely-relate ...[more]