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The dorsal posterior insula subserves a fundamental role in human pain.

ABSTRACT: Several brain regions have been implicated in human painful experiences, but none have been proven to be specific to pain. We exploited arterial spin-labeling quantitative perfusion imaging and a newly developed procedure to identify a specific role for the dorsal posterior insula (dpIns) in pain. Tract tracing studies in animals identify a similar region as fundamental to nociception, which suggests the dpIns is its human homolog and, as such, a potential therapeutic target.

SUBMITTER: Segerdahl AR

PROVIDER: S-EPMC6783299 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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The dorsal posterior insula subserves a fundamental role in human pain.

Segerdahl Andrew R AR Mezue Melvin M Okell Thomas W TW Farrar John T JT Tracey Irene I

Nature neuroscience 20150309 4

Several brain regions have been implicated in human painful experiences, but none have been proven to be specific to pain. We exploited arterial spin-labeling quantitative perfusion imaging and a newly developed procedure to identify a specific role for the dorsal posterior insula (dpIns) in pain. Tract tracing studies in animals identify a similar region as fundamental to nociception, which suggests the dpIns is its human homolog and, as such, a potential therapeutic target. ...[more]

PMID: 25751532

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