Ontology highlight
ABSTRACT:
SUBMITTER: Goyard D
PROVIDER: S-EPMC6783499 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Goyard David D Thomas Baptiste B Gillon Emilie E Imberty Anne A Renaudet Olivier O
Frontiers in chemistry 20191002
Multivalent structures displaying different instead of similar sugar units, namely heteroglycoclusters (hGCs), are stimulating the efforts of glycochemists for developing compounds with new biological properties. Here we report a four-step strategy to synthesize hexadecavalent hGCs displaying eight copies of αFuc and βGal. These compounds were tested for the binding to lectins LecA and LecB from <i>Pseudomonas aeruginosa</i>. While parent fucosylated (<b>19</b>) and galactosylated (<b>20</b>) ho ...[more]