Ontology highlight
ABSTRACT:
SUBMITTER: Ulloa V
PROVIDER: S-EPMC6783570 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Ulloa Viviana V Saldivia Natalia N Ferrada Luciano L Salazar Katterine K Martínez Fernando F Silva-Alvarez Carmen C Magdalena Rocio R Oviedo María José MJ Montecinos Hernán H Torres-Vergara Pablo P Cifuentes Manuel M Nualart Francisco F
Scientific reports 20191008 1
Vitamin C is incorporated into the cerebrospinal fluid (CSF) through choroid plexus cells. While the transfer of vitamin C from the blood to the brain has been studied functionally, the vitamin C transporter, SVCT2, has not been detected in the basolateral membrane of choroid plexus cells. Furthermore, it is unknown how its expression is induced in the developing brain and modulated in scurvy conditions. We concluded that SVCT2 is intensely expressed in the second half of embryonic brain develop ...[more]