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Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy.

ABSTRACT: Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause respiratory infections. These viruses are particularly pathogenic in healthy and immune-compromised individuals, and currently, no adenovirus vaccine is available for the general public. The purpose of this review is to describe (i) the epidemiology and pathogenicity of human adenoviruses, (ii) the biological role of adenovirus vectors in gene therapy applications, and (iii) the potential role of exosomes in adenoviral infections.

SUBMITTER: Crenshaw BJ

PROVIDER: S-EPMC6784011 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy.

Crenshaw Brennetta J BJ Jones Leandra B LB Bell Courtnee' R CR Kumar Sanjay S Matthews Qiana L QL

Biomedicines 20190819 3

Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause respiratory infections. These viruses are particularly pathogenic in healthy and immune-compromised individuals, and currently, no adenovirus vaccine is available for the general public. The purpose of this review is to describe (i) the epidemiology and pathogenicity of human adenoviruses, (ii) the biological role of adenovirus vectors in gene therapy applications, and (iii) the potential role of exosomes in adenovira ...[more]

PMID: 31430920

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