Immunotherapy for pediatric brain tumors: past and present.
Ontology highlight
ABSTRACT:
SUBMITTER: Foster JB
PROVIDER: S-EPMC6784275 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Immunotherapy for pediatric brain tumors: past and present.
Foster Jessica B JB Madsen Peter J PJ Hegde Meenakshi M Ahmed Nabil N Cole Kristina A KA Maris John M JM Resnick Adam C AC Storm Phillip B PB Waanders Angela J AJ
Neuro-oncology 20191001 10
The field of cancer immunotherapy has progressed at an accelerated rate over the past decade. Pediatric brain tumors thus far have presented a formidable challenge for immunotherapy development, given their typically low mutational burden, location behind the blood-brain barrier in a unique tumor microenvironment, and intratumoral heterogeneity. Despite these challenges, recent developments in the field have resulted in exciting preclinical evidence for various immunotherapies and multiple clini ...[more]
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