Ontology highlight
ABSTRACT:
SUBMITTER: Gartlan KH
PROVIDER: S-EPMC6784518 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Gartlan Kate H KH Koyama Motoko M Lineburg Katie E KE Chang Karshing K Ensbey Kathleen S KS Kuns Rachel D RD Henden Andrea S AS Samson Luke D LD Clouston Andrew D AD Lopez Angel F AF MacDonald Kelli P A KPA Hill Geoffrey R GR
Blood advances 20191001 19
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has recently emerged as an important pathogenic cytokine in acute graft-versus-host disease (GVHD), but the nature of the T-cell lineages secreting the cytokine and the mechanisms of action are less clear. Here we used interleukin 17A-fate reporter systems with transcriptional analysis and assays of alloantigen presentation to interrogate the origins of GM-CSF-secreting T cells and the effects of the cytokine on antigen-presenting cell (A ...[more]