New insights from uncultivated genomes of the global human gut microbiome.
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ABSTRACT:
SUBMITTER: Nayfach S
PROVIDER: S-EPMC6784871 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
New insights from uncultivated genomes of the global human gut microbiome.
Nayfach Stephen S Shi Zhou Jason ZJ Seshadri Rekha R Pollard Katherine S KS Kyrpides Nikos C NC
Nature 20190313 7753
The genome sequences of many species of the human gut microbiome remain unknown, largely owing to challenges in cultivating microorganisms under laboratory conditions. Here we address this problem by reconstructing 60,664 draft prokaryotic genomes from 3,810 faecal metagenomes, from geographically and phenotypically diverse humans. These genomes provide reference points for 2,058 newly identified species-level operational taxonomic units (OTUs), which represents a 50% increase over the previousl ...[more]
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