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Designing Photolabile Ruthenium Polypyridyl Crosslinkers for Hydrogel Formation and Multiplexed, Visible-light Degradation.

ABSTRACT: Photoresponsive materials afford spatiotemporal control over desirable physical, chemical and biological properties. For advanced applications, there is need for molecular phototriggers that are readily incorporated within larger structures, and spatially-sequentially addressable with different wavelengths of visble light, enabling multiplexing. Here we describe spectrally tunable (?max = 420-530 nm) ruthenium polypyridyl complexes functionalized with two photolabile nitrile ligands that present terminal alkynes for subsequent crosslinking reactions, including hydrogel formation. Two Ru crosslinkers were incorporated within a PEG-hydrogel matrix, and sequentially degraded by irradiation with 592 nm and 410 nm light.

SUBMITTER: Rapp TL

PROVIDER: S-EPMC6785243 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Designing Photolabile Ruthenium Polypyridyl Crosslinkers for Hydrogel Formation and Multiplexed, Visible-light Degradation.

Rapp Teresa L TL Wang Yanfei Y Delessio Maegan A MA Gau Michael R MR Dmochowski Ivan J IJ

RSC advances 20190208 9

Photoresponsive materials afford spatiotemporal control over desirable physical, chemical and biological properties. For advanced applications, there is need for molecular phototriggers that are readily incorporated within larger structures, and spatially-sequentially addressable with different wavelengths of visble light, enabling multiplexing. Here we describe spectrally tunable (λ<sub>max</sub> = 420-530 nm) ruthenium polypyridyl complexes functionalized with two photolabile nitrile ligands t ...[more]

PMID: 31598214

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