Ontology highlight
ABSTRACT:
SUBMITTER: Adeluyi A
PROVIDER: S-EPMC6785260 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Science advances 20191009 10
Smoking is the largest preventable cause of death and disease in the United States. However, <5% of quit attempts are successful, underscoring the urgent need for novel therapeutics. Microglia are one untapped therapeutic target. While previous studies have shown that microglia mediate both inflammatory responses in the brain and brain plasticity, little is known regarding their role in nicotine dependence and withdrawal phenotypes. Here, we examined microglial changes in the striatum-a mesolimb ...[more]