Ontology highlight
ABSTRACT:
SUBMITTER: Dong Y
PROVIDER: S-EPMC6785365 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Dong Yunzhu Y Zhao Xinghui X Feng Xiaomin X Zhou Yile Y Yan Xiaomei X Zhang Ya Y Bu Jiachen J Zhan Di D Hayashi Yoshihiro Y Zhang Yue Y Xu Zefeng Z Huang Rui R Wang Jieyu J Zhao Taoran T Xiao Zhijian Z Ju Zhenyu Z Andreassen Paul R PR Wang Qian-Fei QF Chen Wei W Huang Gang G
Leukemia 20190409 11
SETD2, an epigenetic tumor suppressor, is frequently mutated in MLL-rearranged (MLLr) leukemia and relapsed acute leukemia (AL). To clarify the impact of SETD2 mutations on chemotherapy sensitivity in MLLr leukemia, two loss-of-function (LOF) Setd2-mutant alleles (Setd2<sup>F2478L/WT</sup> or Setd2<sup>Ex6-KO/WT</sup>) were generated and introduced, respectively, to the Mll-Af9 knock-in leukemia mouse model. Both alleles cooperated with Mll-Af9 to accelerate leukemia development that resulted in ...[more]