Dataset Information

Relationships between [¹?F]-THK5351 Retention and Language Functions in Primary Progressive Aphasia.

ABSTRACT:

Background and purpose

There are three distinct subtypes of primary progressive aphasia (PPA): the nonfluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA). We sought to characterize the pattern of [¹?F]-THK5351 retention across all three subtypes and determine the topography of [¹?F]-THK5351 retention correlated with each neurolinguistic score.

Methods

We enrolled 50 participants, comprising 13 PPA patients (3 nfvPPA, 5 svPPA, and 5 lvPPA) and 37 subjects with normal cognition (NC) who underwent 3.0-tesla magnetic resonance imaging, [¹?F]-THK5351 positron-emission tomography scans, and detailed neuropsychological tests. The PPA patients additionally participated in extensive neurolinguistic tests. Voxel-wise and region-of-interest-based analyses were performed to analyze [¹?F]-THK5351 retention.

Results

The nfvPPA patients exhibited higher [¹?F]-THK5351 retention in the the left inferior frontal and precentral gyri. In svPPA patients, [¹?F]-THK5351 retention was elevated in the anteroinferior and lateral temporal cortices compared to the NC group (left>right). The lvPPA patients exhibited predominant [¹?F]-THK5351 retention in the inferior parietal, lateral temporal, and dorsolateral prefrontal cortices, and the precuneus (left>right). [¹?F]-THK5351 retention in the left inferior frontal area was associated with lower fluency scores. Comprehension was correlated with [¹?F]-THK5351 retention in the left temporal cortices. Repetition was associated with [¹?F]-THK5351 retention in the left inferior parietal and posterior temporal areas, while naming difficulty was correlated with retention in the left fusiform and temporal cortices.

Conclusions

The pattern of [¹?F]-THK5351 retention was well matched with clinical and radiological findings for each PPA subtype, in agreement with the anatomical and functional location of each language domain.

SUBMITTER: Jeong HJ

PROVIDER: S-EPMC6785468 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Relationships between [¹⁸F]-THK5351 Retention and Language Functions in Primary Progressive Aphasia.

Jeong Hye Jin HJ Yoon Cindy W CW Seo Seongho S Lee Sang Yoon SY Suh Mee Kyung MK Seo Ha Eun HE Kim Woo Ram WR Lee Hyon H Heo Jae Hyeok JH Lee Yeong Bae YB Park Kee Hyung KH Choi Seong Hye SH Ido Tatsuo T Lee Kyoung Min KM Noh Young Y

Journal of clinical neurology (Seoul, Korea) 20191001 4

<h4>Background and purpose</h4>There are three distinct subtypes of primary progressive aphasia (PPA): the nonfluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA). We sought to characterize the pattern of [¹⁸F]-THK5351 retention across all three subtypes and determine the topography of [¹⁸F]-THK5351 retention correlated with each neurolinguistic score.<h4>Methods</h4>We enrolled 50 participants, comprising 13 PPA patients (3 nfvPPA, 5 svPPA, and 5 l ...[more]

PMID: 31591842

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