Blue laser light inhibits biofilm formation in vitro and in vivo by inducing oxidative stress.
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ABSTRACT:
SUBMITTER: Rupel K
PROVIDER: S-EPMC6785554 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Blue laser light inhibits biofilm formation in vitro and in vivo by inducing oxidative stress.
Rupel Katia K Zupin Luisa L Ottaviani Giulia G Bertani Iris I Martinelli Valentina V Porrelli Davide D Vodret Simone S Vuerich Roman R Passos da Silva Daniel D Bussani Rossana R Crovella Sergio S Parsek Matthew M Venturi Vittorio V Di Lenarda Roberto R Biasotto Matteo M Zacchigna Serena S
NPJ biofilms and microbiomes 20191009 1
Resolution of bacterial infections is often hampered by both resistance to conventional antibiotic therapy and hiding of bacterial cells inside biofilms, warranting the development of innovative therapeutic strategies. Here, we report the efficacy of blue laser light in eradicating <i>Pseudomonas aeruginosa</i> cells, grown in planktonic state, agar plates and mature biofilms, both in vitro and in vivo, with minimal toxicity to mammalian cells and tissues. Results obtained using knock-out mutant ...[more]
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