Ontology highlight
ABSTRACT:
SUBMITTER: Xue M
PROVIDER: S-EPMC6785563 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nature communications 20191009 1
N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most prevalent internal modification of mRNAs in most eukaryotes. Here we show that RNAs of human respiratory syncytial virus (RSV) are modified by m<sup>6</sup>A within discreet regions and that these modifications enhance viral replication and pathogenesis. Knockdown of m<sup>6</sup>A methyltransferases decreases RSV replication and gene expression whereas knockdown of m<sup>6</sup>A demethylases has the opposite effect. The G gene transcri ...[more]