Task-evoked Negative BOLD Response and Functional Connectivity in the Default Mode Network are Representative of Two Overlapping but Separate Neurophysiological Processes.

ABSTRACT: The topography of the default mode network (DMN) can be obtained with one of two different functional magnetic resonance imaging (fMRI) methods: either from the spontaneous but organized synchrony of the low-frequency fluctuations in resting-state fMRI (rs-fMRI), known as "functional connectivity", or from the consistent and robust deactivations in task-based fMRI (tb-fMRI), here referred to as the "negative BOLD response" (NBR). These two methods are fundamentally different, but their results are often used interchangeably to describe the brain's resting-state, baseline, or intrinsic activity. While the DMN was initially defined by consistent task-based decreases in blood flow in a set of specific brain regions using PET imaging, recently nearly all studies on the DMN employ functional co

SUBMITTER: Parker DB 

PROVIDER: S-EPMC6785640 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature