Dataset Information

Intact responses to non-drug rewards in long-term opioid maintenance treatment.

ABSTRACT: Disruption of non-drug reward processing in addiction could stem from long-term drug use, addiction-related psychosocial stress, or a combination of these. It remains unclear whether long-term opioid maintenance treatment (OMT) disrupts reward processing. Here, we measured subjective and objective reward responsiveness in 26 previously heroin-addicted mothers in >7 years stable OMT with minimal psychosocial stress and illicit drug use. The comparison group was 30 healthy age-matched mothers (COMP). Objective reward responsiveness was assessed in a two-alternative forced-choice task with skewed rewards. Results were also compared to performance from an additional 968 healthy volunteers (meta-analytic approach). We further compared subprocesses of reward-based decisions across groups using computational modelling with a Bayesian drift diffusion model of decision making. Self-reported responsiveness to non-drug rewards was high for both groups (means: OMT?=?6.59, COMP?=?6.67, p?=?0.84, BF₁₀?=?0.29), yielding moderate evidence against subjective anhedonia in this OMT group. Importantly, the mothers in OMT also displayed robust reward responsiveness in the behavioral task (t₁₉?=?2.72, p?=?0.013, BF₁₀?=?3.98; d?=?0.61). Monetary reward changed their task behavior to the same extent as the local comparison group (reward bias OMT?=?0.12, COMP?=?0.12, p?=?0.96, BF₁₀?=?0.18) and in line with data from 968 healthy controls previously tested. Computational modelling revealed that long-term OMT did not even change decision subprocesses underpinning reward behavior. We conclude that reduced sensitivity to rewards and anhedonia are not necessary consequences of prolonged opioid use.

SUBMITTER: Eikemo M

PROVIDER: S-EPMC6785711 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Intact responses to non-drug rewards in long-term opioid maintenance treatment.

Eikemo Marie M Lobmaier Philipp P PP Pedersen Mads L ML Kunøe Nikolaj N Matziorinis Anna Maria AM Leknes Siri S Sarfi Monica M

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20190331 8

Disruption of non-drug reward processing in addiction could stem from long-term drug use, addiction-related psychosocial stress, or a combination of these. It remains unclear whether long-term opioid maintenance treatment (OMT) disrupts reward processing. Here, we measured subjective and objective reward responsiveness in 26 previously heroin-addicted mothers in >7 years stable OMT with minimal psychosocial stress and illicit drug use. The comparison group was 30 healthy age-matched mothers (COM ...[more]

PMID: 30928994

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Dataset Information

Intact responses to non-drug rewards in long-term opioid maintenance treatment.

Publications

Intact responses to non-drug rewards in long-term opioid maintenance treatment.

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