A human gut bacterial genome and culture collection for improved metagenomic analyses.
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ABSTRACT:
SUBMITTER: Forster SC
PROVIDER: S-EPMC6785715 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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A human gut bacterial genome and culture collection for improved metagenomic analyses.
Forster Samuel C SC Kumar Nitin N Anonye Blessing O BO Almeida Alexandre A Viciani Elisa E Stares Mark D MD Dunn Matthew M Mkandawire Tapoka T TT Zhu Ana A Shao Yan Y Pike Lindsay J LJ Louie Thomas T Browne Hilary P HP Mitchell Alex L AL Neville B Anne BA Finn Robert D RD Lawley Trevor D TD
Nature biotechnology 20190204 2
Understanding gut microbiome functions requires cultivated bacteria for experimental validation and reference bacterial genome sequences to interpret metagenome datasets and guide functional analyses. We present the Human Gastrointestinal Bacteria Culture Collection (HBC), a comprehensive set of 737 whole-genome-sequenced bacterial isolates, representing 273 species (105 novel species) from 31 families found in the human gastrointestinal microbiota. The HBC increases the number of bacterial geno ...[more]
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