Ontology highlight
ABSTRACT:
SUBMITTER: Sharipova RR
PROVIDER: S-EPMC6786240 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Sharipova Radmila R RR Belenok Mayya G MG Garifullin Bulat F BF Sapunova Anastasiya S AS Voloshina Alexandra D AD Andreeva Olga V OV Strobykina Irina Yu IY Skvortsova Polina V PV Zuev Yuriy F YF Kataev Vladimir E VE
MedChemComm 20190620 8
A series of glycosides and glycoconjugates of diterpenoid isosteviol (16-oxo-<i>ent</i>-beyeran-19-oic acid) with various monosaccharide residues were synthesized and their cytotoxicity against some human cancer and normal cell lines was assayed. Most of the synthesized compounds demonstrated moderate to significant cytotoxicity against human cancer cell lines M-HeLa and MCF-7. Three lead compounds exhibited selective cytotoxic activities against M-HeLa (IC<sub>50</sub> = 10.0-15.1 μM) that were ...[more]