Dataset Information

Does antibiotic use accelerate or retard cutaneous repair? A systematic review in animal models.

ABSTRACT:

Background

The presence of infections is one of the main factors that leads to delays in healing or non-closure of cutaneous wounds. Although the goal of antibiotic use is to treat or prevent infection, there is currently no agreement on the effectiveness of these products.

Aim

The aim of this study was to evaluate the efficacy of antibiotic use during the healing process of skin wounds in animal models not intentionally infected, as well as to analyze the advances and limitations of the studies carried out in this field.

Main methods

This systematic review was performed according to the PRISMA guidelines, using a structured search on the MedLine (PubMed) and Scopus platforms to retrieve studies published until August 29, 2018, 13:35p.m. The studies included were limited to those that used excision or incision wound models and that were not intentionally infected. The data for the animal models, antibiotic used, and the main results of the studies were extracted, and compared where possible. Bias analysis and methodological quality assessments were examined through the SYRCLE's Risk of Bias tool.

Key findings

Twenty-seven studies were selected. Overall, the effects of the antibiotic on the wound decreased inflammatory cell infiltration and promoted an increased number of fibroblasts, extracellular matrix constituents, re-epithelialization and tissue strength. A great deal of important information about the methodology was not presented, such as: the statistical analysis used, the animal model (sex and age), antibiotic dosage, blinding and randomization of the animals chosen.

Significance

Based on the results found, we believe that antibiotic therapy can be considered a viable alternative for the treatment of cutaneous wounds. However, current evidence obtained from the methodological quality analysis points towards a high risk of bias. This is due to the incomplete characterization of the experimental design and treatment protocol, which compromises the reproducibility of the studies.

SUBMITTER: Altoe LS

PROVIDER: S-EPMC6786583 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Does antibiotic use accelerate or retard cutaneous repair? A systematic review in animal models.

Altoé Luciana Schulthais LS Alves Raul Santos RS Sarandy Mariáurea Matias MM Morais-Santos Mônica M Novaes Rômulo Dias RD Gonçalves Reggiani Vilela RV

PloS one 20191010 10

<h4>Background</h4>The presence of infections is one of the main factors that leads to delays in healing or non-closure of cutaneous wounds. Although the goal of antibiotic use is to treat or prevent infection, there is currently no agreement on the effectiveness of these products.<h4>Aim</h4>The aim of this study was to evaluate the efficacy of antibiotic use during the healing process of skin wounds in animal models not intentionally infected, as well as to analyze the advances and limitations ...[more]

PMID: 31600279

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Dataset Information

Does antibiotic use accelerate or retard cutaneous repair? A systematic review in animal models.

Background

Aim

Main methods

Key findings

Significance

Publications

Does antibiotic use accelerate or retard cutaneous repair? A systematic review in animal models.

Similar Datasets

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