Comprehensive MR Analysis of Cardiac Function, Aortic Hemodynamics and Left Ventricular Strain in Pediatric Cohort with Isolated Bicuspid Aortic Valve.

ABSTRACT: Bicuspid aortic valve (BAV) disease demonstrates a range of clinical presentations and complications. We aim to use cardiac MRI (CMR) to evaluate left ventricular (LV) parameters, myocardial strain and aortic hemodynamics in pediatric BAV patients with and without aortic stenosis (AS) or regurgitation (AR) compared to tricuspid aortic valve (TAV) controls. We identified 58 pediatric BAV patients without additional cardiovascular pathology and 25 healthy TAV controls (15.3?±?2.2 years) who underwent CMR with 4D flow. BAV cohort included subgroups with no valvulopathy (n?=?13, 14.3?±?4.7 years), isolated AS (n?=?19, 14.5?±?4.0 years), mixed valve disease (AS?+?AR) (n?=?13, 17.1?±?3.2 years), and prior valvotomy/valvuloplasty (n?=?13, 13.9?±?3.2 years). CMR data included LV volumetric and mass indices, myocardial strain and aortic hemodynamics. BAV patients with no valvulopathy or isolated AS had similar LV parameters to controls excepting cardiac output (p?

SUBMITTER: Stefek HA 

PROVIDER: S-EPMC6786923 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature