Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis.

ABSTRACT: Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways and evade innate immune response by modulating key host factors and signaling pathways. A collective view of these multiple studies could advance our understanding of virus-host interactions and provide new therapeutic perspectives for the treatment of viral diseases. Here, we performed an integrative meta-analysis to elucidate the 17 different host-virus interactomes. Network and bioinformatics analyses showed how viruses with small genomes efficiently achieve the maximal effect by targeting multifunctional and highly connected host proteins with a high occurrence of

SUBMITTER: Bosl K 

PROVIDER: S-EPMC6787150 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature